Record in detail
General Info
- lamp_id:L03A000248
- Name:DEFB1_CHILA
- FullName:Beta-defensin 1
- Source:Chinchilla lanigera
- Mass:7676.2 Da
- Sequence Length:67 aa
- Isoelectric Point:11.03
- Activity:Antimicrobial
- Sequence
MRIHYLLFAVLFLFLMPVPGEGGIINTIQRYFCRVRGGRCAALTCLPRETQIGRCSVKGRKCCRTRK - Function:Has antibacterial activity against Gram-positive bacterium S.pneumoniae Serotype 14. Is also active against Gram-negative bacteria M.catarrhalis 1857, and non-typeable H.influenzae strains 86-028NP and 1128. Has antifungal activity against C.albicans. May have a role in maintaining sterility in the middle ear.
Cross-Linking
- Cross-linking
- 1 Database:dbAMP dbAMP_09027
- 2 Database:Uniprot P83943
- 3 Database:AMD BD01_CHILA
Top similar AMPs
- Top similar AMPs on LAMP
- 1. L03A000248 From 1 To 67 E-value: 2e-34 Score: 135
MRIHYLLFAVLFLFLMPVPGEGGIINTIQRYFCRVRGGRCAALTCLPRETQIGRCSVKGRKCCRTRK - 2. L03A000252 From 1 To 67 E-value: 2e-22 Score: 95.9
MRIHYLLFTLLFLFLVPVPGHGGIINTLQKYYCRVRGGRCAVLSCLPKEEQIGKCSTRGRKCCRRKK - 3. L03A000247 From 1 To 67 E-value: 2e-22 Score: 95.9
MRIHYLLFALLFLFLVPVPGHGGIINTLQKYYCRVRGGRCAVLSCLPKEEQIGKCSTRGRKCCRRKK - 4. L03A000245 From 1 To 67 E-value: 3e-22 Score: 95.5
MRIHYLLFALLFLFLVPVPGHGGIINTLQKYYCRVRGGRCALLSCLPKEEQIGKCSTRGRKCCRRKK - 5. L03A000246 From 1 To 67 E-value: 8e-22 Score: 94
MRIHYLLFALLFLFLVPVPGHGGIINTLQKYYCRVRGGRCAVLSCLPKEEQIGKCPMRGRKCCRRKK
Structure
- Domains
- 1 Name:Defensin_beta-typ Interpro Link:IPR001855
- Structures
No structs found on LAMP database
Activity
- Antibacterial Activities
No MICs found on LAMP database
Toxicity
- Toxicity
No toxicity records found on LAMP database
Reference
- Reference
- [1] Bakaletz L.O.,Munson R.S. Jr.,Bevins C.L.,Wilk D.,Harris R.H.,
- Title:Identification and characterization of mucosal antimicrobial peptides expressed by the chinchilla (Chinchilla lanigera) airway.
- Journal:J. Biol. Chem., 2004, 279, 20250-20256 [PubMed:14996845]
Comments
- Comments
No comments found on LAMP database