Record in detail


General Info

  • lamp_id:L03A000248
  • Name:DEFB1_CHILA
  • FullName:Beta-defensin 1
  • Source:Chinchilla lanigera
  • Mass:7676.2 Da
  • Sequence Length:67 aa
  • Isoelectric Point:11.03
  • Activity:Antimicrobial
  • Sequence
        MRIHYLLFAVLFLFLMPVPGEGGIINTIQRYFCRVRGGRCAALTCLPRETQIGRCSVKGRKCCRTRK
  • Function:Has antibacterial activity against Gram-positive bacterium S.pneumoniae Serotype 14. Is also active against Gram-negative bacteria M.catarrhalis 1857, and non-typeable H.influenzae strains 86-028NP and 1128. Has antifungal activity against C.albicans. May have a role in maintaining sterility in the middle ear.

Cross-Linking

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L03A000248    From 1 To 67 E-value: 2e-34 Score: 135
        MRIHYLLFAVLFLFLMPVPGEGGIINTIQRYFCRVRGGRCAALTCLPRETQIGRCSVKGRKCCRTRK
  • 2. L03A000252    From 1 To 67 E-value: 2e-22 Score: 95.9
        MRIHYLLFTLLFLFLVPVPGHGGIINTLQKYYCRVRGGRCAVLSCLPKEEQIGKCSTRGRKCCRRKK
  • 3. L03A000247    From 1 To 67 E-value: 2e-22 Score: 95.9
        MRIHYLLFALLFLFLVPVPGHGGIINTLQKYYCRVRGGRCAVLSCLPKEEQIGKCSTRGRKCCRRKK
  • 4. L03A000245    From 1 To 67 E-value: 3e-22 Score: 95.5
        MRIHYLLFALLFLFLVPVPGHGGIINTLQKYYCRVRGGRCALLSCLPKEEQIGKCSTRGRKCCRRKK
  • 5. L03A000246    From 1 To 67 E-value: 8e-22 Score: 94
        MRIHYLLFALLFLFLVPVPGHGGIINTLQKYYCRVRGGRCAVLSCLPKEEQIGKCPMRGRKCCRRKK

Structure

  •   Domains
  •   1  Name:Defensin_beta-typ    Interpro Link:IPR001855
  •   Structures

        No structs found on LAMP database

Activity

  •   Antibacterial Activities

  •     No MICs found on LAMP database

Toxicity

  •   Toxicity

  •     No toxicity records found on LAMP database

Reference

  •   Reference
  •   [1]  Bakaletz L.O.,Munson R.S. Jr.,Bevins C.L.,Wilk D.,Harris R.H.,
  •   Title:Identification and characterization of mucosal antimicrobial peptides expressed by the chinchilla (Chinchilla lanigera) airway.
  •   Journal:J. Biol. Chem., 2004, 279, 20250-20256  [PubMed:14996845]

Comments

  •   Comments

  •     No comments found on LAMP database



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