Record in detail
General Info
- lamp_id:L03A000261
- Name:DFB12_BOVIN
- FullName:Beta-defensin 12
- Source:Bos taurus
- Mass:6463.8 Da
- Sequence Length:60 aa
- Isoelectric Point:10.09
- Activity:Antimicrobial
- Sequence
MRLHHLLLALLFLVLSAASGISGPLSCGRNGGVCIPIRCPVPMRQIGTCFGRPVKCCRSW - Function:Has bactericidal activity. Active against E.coli ML35 and S.aureus 502A.
Cross-Linking
- Cross-linking
- 1 Database:CAMP CAMPSQ6731
- 2 Database:dbAMP dbAMP_09072
- 3 Database:Uniprot P46170
- 4 Database:AMD BD12_BOVIN
Top similar AMPs
- Top similar AMPs on LAMP
- 1. L03A000261 From 1 To 60 E-value: 1e-29 Score: 119
MRLHHLLLALLFLVLSAASGISGPLSCGRNGGVCIPIRCPVPMRQIGTCFGRPVKCCRSW - 2. L03A000070 From 1 To 53 E-value: 2e-21 Score: 92.4
LALLFLVLSAGSGISGPLSCRRKGGICILIRCPGPMRQIGTCFGRPVKCCRSW - 3. L01A000072 From 1 To 42 E-value: 1e-19 Score: 86.7
SGISGPLSCGRNGGVCIPIRCPVPMRQIGTCFGRPVKCCRSW - 4. L12A09080| From 1 To 60 E-value: 2e-19 Score: 86.3
MRLHHLLLALLFLVLSAGSGISGPLSCRRNGGVCIPIRCPGPMRQIGTCFGRPVKCCRSW - 5. L12A09071| From 1 To 64 E-value: 5e-19 Score: 84.7
MRLHHLLLALLFLVLSAASGFTQGISGPLSCGRNGGVCIPIRCPVPMRQIGTCFRRPVKCCRSW
Activity
- Antibacterial Activities
No MICs found on LAMP database
Toxicity
- Toxicity
No toxicity records found on LAMP database
Reference
- Reference
- [1] Selsted M.E.,Tang Y.-Q.,
- Title:Characterization of the disulfide motif in BNBD-12, an antimicrobial beta-defensin peptide from bovine neutrophils.
- Journal:J. Biol. Chem., 1993, 268, 6649-6653 [MEDLINE:93203265]
- [2] Novotny M.J.,McGuire P.A.,Morris W.L.,Tang Y.-Q.,Selsted M.E.,
- Title:Purification, primary structures, and antibacterial activities of beta-defensins, a new family of antimicrobial peptides from bovine neutrophils.
- Journal:J. Biol. Chem., 1993, 268, 6641-6648 [MEDLINE:93203264]
- [3] Pardi A.,Selsted M.E.,Legault P.,Zimmermann G.R.,
- Title:Solution structure of bovine neutrophil beta-defensin-12: the peptide fold of the beta-defensins is identical to that of the classical defensins.
- Journal:Biochemistry, 1995, 34, 13663-13671 [MEDLINE:96027485]
Comments
- Comments
No comments found on LAMP database