Record in detail


General Info

  • lamp_id:L03A000273
  • Name:DEF4_MACMU
  • FullName:Neutrophil defensin 4
  • Source:Macaca mulatta
  • Mass:10352.5 Da
  • Sequence Length:94 aa
  • Isoelectric Point:7.73
  • Activity:Antimicrobial
  • Sequence
        MRTIAILAAILLFALLAQAKSLQETADDAATQEQPGEDDQDLAVSFEENGLSTLRASGSQARRTCRCRFGRCFRRESYSGSCNINGRIFSLCCR
  • Function:Defensins 4 and 5 have bacteriostatic activity against Gram-positive bacteria S.aureus and L.monocytogenes and Gram-negative bacterium E.coli, antifungal activity against C.neoformans and microbicidial activity against Gram-positive bacteria S.aureus and L.monocytogenes.

Cross-Linking

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L03A000273    From 1 To 94 E-value: 0 Score: 188
        MRTIAILAAILLFALLAQAKSLQETADDAATQEQPGEDDQDLAVSFEENGLSTLRASGSQARRTCRCRFGRCFRRESYSGSCNINGRIFSLCCR
  • 2. L03A000276    From 1 To 94 E-value: 0 Score: 187
        MRTLAILAAILLFALLAQAKSLQETADDAATQEQPGEDDQDLAVSFEENGLSTLRASGSQARRTCRCRFGRCFRRESYSGSCNINGRIFSLCCR
  • 3. L12A09204|    From 1 To 93 E-value: 3.9937e-43 Score: 164
        MRTLAILAAILLFTLLAQAKSLQERADDAATQEQPGEDDQDLAVSFEENGLSTLRDSGSQARRTCHCR-SRCLRRESNSGSCNINGRIFSLCCR
  • 4. L12A09205|    From 1 To 93 E-value: 3.00018e-42 Score: 161
        MRTLAILAAILLFTLLAQAKSLQERADDAATQEQPGEDDQDLAVSFEENGLSTLRDSGSQARRTCHCR-SRCLRRESNSGSCNINGRISSLCCR
  • 5. L12A09238|    From 1 To 94 E-value: 3e-40 Score: 155
        MRTLTILAAILLVALQAQAESLQERADEAATQEQPGEDDQDLAVSFEENGLSTLRASGSQARRTCYCRIGRCFRRESSSGRCRISGRIYILCCH

Structure

  •   Domains
  •   1  Name:Alpha-defensin    Interpro Link:IPR016327
  •   2  Name:Defensin_beta/neutrophil    Interpro Link:IPR006080
  •   3  Name:Defensin_propep    Interpro Link:IPR002366
  •   4  Name:Mammalian_defensins    Interpro Link:IPR006081
  •   Structures

        No structs found on LAMP database

Activity

  •   Antibacterial Activities

    •     No MICs found on LAMP database

Toxicity

  •   Toxicity

    •     No toxicity records found on LAMP database

Reference

  •   Reference
  •   [1]  Selsted M.E.,Miller C.J.,Yuan J.,Tang Y.Q.,
  •   Title:Isolation, characterization, cDNA cloning, and antimicrobial properties of two distinct subfamilies of alpha-defensins from rhesus macaque leukocytes.
  •   Journal:Infect. Immun., 1999, 67, 6139-6144  [MEDLINE:20002603]

Comments

  •   Comments

    •     No comments found on LAMP database



CAPTCHA Image   Reload Image
Enter Code*: