Record in detail


General Info

  • lamp_id:L03A000275
  • Name:DEF5_HUMAN
  • FullName:Defensin-5
  • Source:Homo sapiens
  • Mass:10071.3 Da
  • Sequence Length:94 aa
  • Isoelectric Point:8.11
  • Activity:Antimicrobial
  • Sequence
        MRTIAILAAILLVALQAQAESLQERADEATTQKQSGEDNQDLAISFAGNGLSALRTSGSQARATCYCRTGRCATRESLSGVCEISGRLYRLCCR
  • Function:Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. All DEFA5 peptides exert antimicrobial activities, but their potency is affected by peptide processing.

Cross-Linking

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L03A000275    From 1 To 94 E-value: 0 Score: 184
        MRTIAILAAILLVALQAQAESLQERADEATTQKQSGEDNQDLAISFAGNGLSALRTSGSQARATCYCRTGRCATRESLSGVCEISGRLYRLCCR
  • 2. L12A09201|    From 1 To 94 E-value: 0 Score: 176
        MRTITILAAILLVALQAQAESLQERADEATTQKQSGEDNQDLAISFAGNGLSALRTSGSQARATCYCRTGPCTNRESLSGVCEISGRLYRFCCR
  • 3. L05ADEF188    From 1 To 94 E-value: 0 Score: 174
        MRTIAILAAILLVALQAQAESLQERADEATTQKQSGEDNQDLAISFAGNGLSALRTSGSQARATCYCRIGHCTILESLSGVCEISGRLYRLCCR
  • 4. L12A08310|    From 1 To 94 E-value: 6e-40 Score: 154
        MKTIAILAAILLVALQAQAESLQERADEAATQKQSGEDNQDLAVSFAGNGLSTLRASDSQARSTCYCRSGLCAAIESYSGRCYISGRRYRLCCR
  • 5. L12A09198|    From 1 To 94 E-value: 6e-40 Score: 154
        MRTIAILAAILLVALQAQAESLQERADEAATQKQSGEDNQDLAVSFAGNGLSTLRASDSQARSTCYCRIGLCAAIESYSGRCYISGRRYRLCCR

Structure

  •   Domains
  •   1  Name:Alpha-defensin    Interpro Link:IPR016327
  •   2  Name:Defensin_beta/neutrophil    Interpro Link:IPR006080
  •   3  Name:Defensin_propep    Interpro Link:IPR002366
  •   4  Name:Mammalian_defensins    Interpro Link:IPR006081
  •   Structures
  •   1
    PDB:1ZMP
    Method:X-ray
    Chains:A/B/C/D=63-94
  •   2
    PDB:3I5W
    Method:X-ray
    Chains:A/B=63-94

Activity

  •   Antibacterial Activities

    •     No MICs found on LAMP database

Toxicity

  •   Toxicity

    •     No toxicity records found on LAMP database

Reference

  •   Reference
  •   [1]  Bevins C.L.,Jones D.E.,
  •   Title:Paneth cells of the human small intestine express an antimicrobial peptide gene.
  •   Journal:J. Biol. Chem., 1992, 267, 23216-23225  [MEDLINE:93054653]
  •   [2]  Wilk D.,Lee S.K.,Shen B.,Porter E.,Ghosh D.,
  •   Title:Paneth cell trypsin is the processing enzyme for human defensin-5.
  •   Journal:Nat. Immunol., 2002, 3, 583-590  [PubMed:12021776]
  •   [3]  
  •   Title:The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
  •   Journal:Genome Res., 2004, 14, 2121-2127  [PubMed:15489334]
  •   [4]  Lehrer R.I.,Lu W.,Wu Z.,Ericksen B.,
  •   Title:Antibacterial activity and specificity of the six human alpha-defensins.
  •   Journal:Antimicrob. Agents Chemother., 2005, 49, 269-275  [PubMed:15616305]
  •   [5]  Lu W.,Yang D.,Tucker K.,Wu Z.,Szyk A.,
  •   Title:Crystal structures of human alpha-defensins HNP4, HD5, and HD6.
  •   Journal:Protein Sci., 2006, 15, 2749-2760  [PubMed:17088326]
  •   [6]  Taudien S.,Asakawa S.,Zody M.C.,Mikkelsen T.S.,Nusbaum C.,
  •   Title:DNA sequence and analysis of human chromosome 8.
  •   Journal:Nature, 2006, 439, 331-335  [PubMed:16421571]

Comments

  •   Comments

    •     No comments found on LAMP database



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