Record in detail


General Info

  • lamp_id:L03A000281
  • Name:DEF5_RABIT
  • FullName:Neutrophil antibiotic peptide NP-4
  • Source:Oryctolagus cuniculus
  • Mass:10180.6 Da
  • Sequence Length:95 aa
  • Isoelectric Point:7.21
  • Activity:Antimicrobial
  • Sequence
        MRTLALLAAILLVTLQAQAELHSGMADDGVDQQQPRAQDLDVAVYIKQDETSPLEVLGAKAGVSCTCRRFSCGFGERASGSCTVNGVRHTLCCRR
  • Function:Microbicidal activity.

Cross-Linking

  •   Cross-linking
  •   1  Database:Uniprot  P07467
  •   2  Database:AMD  DEF5_RABIT

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L03A000281    From 1 To 95 E-value: 0 Score: 193
        MRTLALLAAILLVTLQAQAELHSGMADDGVDQQQPRAQDLDVAVYIKQDETSPLEVLGAKAGVSCTCRRFSCGFGERASGSCTVNGVRHTLCCRR
  • 2. L03A000280    From 1 To 95 E-value: 8.99634e-43 Score: 163
        MRTLALLAAILLVTLQAQAELHSGMADDGVDQQQPRAQDLDVAVYIKQDETSPLEVLGAKAGVFCTCRGFLCGSGERASGSCTINGVRHTLCCRR
  • 3. L05ADEF181    From 1 To 93 E-value: 2e-19 Score: 86.7
        MRTLTLLSAFLLVALQAWAEPLQARADEMPAQKQPPADDQDVVIYFSGDDSSSLQVPGSTKGLICHCRVLYCLFGEHLGGTSFIHGERYPICC
  • 4. L03A000279    From 1 To 95 E-value: 2e-19 Score: 85.9
        MRTLALLAAILLVALQAQAEHVSVSIDEVVDQQPPQAEDQDVAIYVKEHESSALEALGVKAGVVCACRRALCLPRERRAGFCRIRGRIHPLCCRR
  • 5. L03A000278    From 1 To 95 E-value: 3e-19 Score: 85.5
        MRTLALLAAILLVALQAQAEHISVSIDEVVDQQPPQAEDQDVAIYVKEHESSALEALGVKAGVVCACRRALCLPLERRAGFCRIRGRIHPLCCRR

Structure

  •   Domains
  •   1  Name:Alpha-defensin    Interpro Link:IPR016327
  •   2  Name:Defensin_beta/neutrophil    Interpro Link:IPR006080
  •   3  Name:Defensin_propep    Interpro Link:IPR002366
  •   4  Name:Mammalian_defensins    Interpro Link:IPR006081
  •   Structures

        No structs found on LAMP database

Activity

  •   Antibacterial Activities

    •     No MICs found on LAMP database

Toxicity

  •   Toxicity

    •     No toxicity records found on LAMP database

Reference

  •   Reference
  •   [1]  Lehrer R.I.,Harwig S.S.L.,Delange R.J.,Brown D.M.,Selsted M.E.,
  •   Title:Primary structures of six antimicrobial peptides of rabbit peritoneal neutrophils.
  •   Journal:J. Biol. Chem., 1985, 260, 4579-4584  [MEDLINE:85182561]
  •   [2]  Ganz T.,Rayner J.R.,Couto M.,Michaelson D.,
  •   Title:Cationic defensins arise from charge-neutralized propeptides: a mechanism for avoiding leukocyte autocytotoxicity?
  •   Journal:J. Leukoc. Biol., 1992, 51, 634-639  [MEDLINE:92308748]

Comments

  •   Comments

    •     No comments found on LAMP database



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