Record in detail


General Info

  • lamp_id:L03A000318
  • Name:PLF4_HUMAN
  • FullName:Platelet factor 4
  • Source:Homo sapiens
  • Mass:1573 Da
  • Sequence Length:13 aa
  • Isoelectric Point:10.48
  • Activity:Antimicrobial
  • Sequence
        PLYKKIIKKLLES
  • Function:Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation, the short form is a more potent inhibitor than the longer form.

Cross-Linking

  •   Cross-linking
  •   1  Database:DBAASP  3903
  •   2  Database:Uniprot  P02776
  •   3  Database:AMD  PF4PF_HUMAN

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L12A01279|    From 58 To 70 E-value: 0.051 Score: 27.3
        PLYKKIIKKLLES
  • 2. L03A000318    From 1 To 13 E-value: 0.11 Score: 26.2
        PLYKKIIKKLLES
  • 3. L11A003904    From 1 To 13 E-value: 0.56 Score: 23.9
        ALYKKIIKKLLES
  • 4. L11A003907    From 1 To 12 E-value: 0.74 Score: 23.5
        LYKKIIKKLLES
  • 5. L11A003908    From 1 To 12 E-value: 2.1 Score: 21.9
        LYAKIIKKLLES

Structure

  •   Domains
  •   1  Name:Chemokine_CXC    Interpro Link:IPR001089
  •   2  Name:Chemokine_CXC_CS    Interpro Link:IPR018048
  •   3  Name:Chemokine_CXCL8/IL8    Interpro Link:IPR002473
  •   4  Name:Chemokine_IL8-like_dom    Interpro Link:IPR001811
  •   Structures
  •   1
    PDB:1DN3
    Method:NMR
    Chains:A=87-101
  •   2
    PDB:1F9Q
    Method:X-ray
    Chains:A/B/C/D=32-101
  •   3
    PDB:1F9R
    Method:X-ray
    Chains:A/B/C/D=32-101
  •   4
    PDB:1F9S
    Method:X-ray
    Chains:A/B/C/D=32-101
  •   5
    PDB:1PFM
    Method:NMR
    Chains:A/B/C/D=43-101
  •   6
    PDB:1PFN
    Method:NMR
    Chains:A/B/C/D=43-101
  •   7
    PDB:1RHP
    Method:X-ray
    Chains:A/B/C/D=32-101

Activity

  •   Antibacterial Activities

    •     No MICs found on LAMP database

Toxicity

  •   Toxicity

    •     No toxicity records found on LAMP database

Reference

  •   Reference
  •   [1]  Heinrikson R.L.,Farmer M.,Keim P.S.,Deuel T.F.,
  •   Title:Amino acid sequence of human platelet factor 4.
  •   Journal:Proc. Natl. Acad. Sci. U.S.A., 1977, 74, 2256-2258  [MEDLINE:77234634]
  •   [2]  Kurachi K.,Schmer G.,Hermodson M.,
  •   Title:Isolation, crystallization, and primary amino acid sequence of human platelet factor 4.
  •   Journal:J. Biol. Chem., 1977, 252, 6276-6279  [MEDLINE:77249569]
  •   [3]  McCoy L.E.,Dene H.,de Lamo R.,Wu V.Y.,Walz D.A.,
  •   Title:Primary structure of human platelet factor 4.
  •   Journal:Thromb. Res., 1977, 11, 893-898  [MEDLINE:78097310]
  •   [4]  Chesterman C.N.,Begg G.S.,Morgan F.J.,
  •   Title:Complete covalent structure of human platelet factor 4.
  •   Journal:Thromb. Haemost., 1980, 42, 1652-1660  [MEDLINE:80169663]
  •   [5]  Rappaport E.F.,Weiss M.J.,Larocco P.,Surrey S.,Poncz M.,
  •   Title:Cloning and characterization of platelet factor 4 cDNA derived from a human erythroleukemic cell line.
  •   Journal:Blood, 1987, 69, 219-223  [MEDLINE:87076954]
  •   [6]  Poncz M.,Schwartz E.,Ramachandran B.,Surrey S.,Eisman R.,
  •   Title:Structural and functional comparison of the genes for human platelet factor 4 and PF4alt.
  •   Journal:Blood, 1990, 76, 336-344  [MEDLINE:90315431]
  •   [7]  Maione T.E.,Lai C.K.,Bancroft D.P.,Chen L.,Zhang X.,
  •   Title:Crystal structure of recombinant human platelet factor 4.
  •   Journal:Biochemistry, 1994, 33, 8361-8366  [MEDLINE:94304848]
  •   [8]  Singh J.P.,Hassel T.,Gupta S.K.,
  •   Title:A potent inhibitor of endothelial cell proliferation is generated by proteolytic cleavage of the chemokine platelet factor 4.
  •   Journal:Proc. Natl. Acad. Sci. U.S.A., 1995, 92, 7799-7803  [PubMed:7644496]
  •   [9]  Feldman M.,Sachis B.S.,Kowalska M.A.,Thornton M.A.,Zhang C.,
  •   Title:Localization of distal regulatory domains in the megakaryocyte-specific platelet basic protein/platelet factor 4 gene locus.
  •   Journal:Blood, 2001, 98, 610-617  [MEDLINE:21361158]
  •   [10]  
  •   Title:The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
  •   Journal:Genome Res., 2004, 14, 2121-2127  [PubMed:15489334]
  •   [11]  Pepin K.H.,Fulton L.A.,Fulton R.S.,Graves T.A.,Hillier L.W.,
  •   Title:Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
  •   Journal:Nature, 2005, 434, 724-731  [PubMed:15815621]

Comments

  •   Comments

    •     No comments found on LAMP database



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