Record in detail
General Info
- lamp_id:L03A000321
- Name:RTD1A_MACMU
- FullName:Rhesus theta defensin-1/3 subunit A
- Source:Macaca mulatta
- Mass:2105.6 Da
- Sequence Length:18 aa
- Isoelectric Point:8.91
- Activity:Antimicrobial
- Sequence
RCICTRGFCRCLCRRGVC - Function:RTD-1 and RTD-3 have similar antimicrobial activities against the Gram-positive bacteria S.aureus 502A and L.monocytogenes, the Gram-negative bacteria S.typhimurium and E.coli ML35, and the fungi C.albicans 16820 and C.neoformans 271A.
Cross-Linking
- Cross-linking
- 1 Database:Uniprot P82270
- 2 Database:AMD TDEF1_MACMU
Top similar AMPs
- Top similar AMPs on LAMP
- 1. L03A000321 From 1 To 18 E-value: 0.0003 Score: 35.4
RCICTRGFCRCLCRRGVC - 2. L02A000151 From 1 To 18 E-value: 0.0008 Score: 33.9
RCVCTRGFCRCVCRRGVC - 3. L02A000856 From 1 To 18 E-value: 0.0009 Score: 33.5
RCVCTRGFCRCFCRRGVC - 4. L02A000725 From 1 To 18 E-value: 0.005 Score: 31.2
RCICTRGFCRCICTRGFC - 5. L02A000804 From 1 To 18 E-value: 0.008 Score: 30.4
RCVCTRGFCRCVCTRGFC
Activity
- Antibacterial Activities
No MICs found on LAMP database
Toxicity
- Toxicity
No toxicity records found on LAMP database
Reference
- Reference
- [1] Tran D.,Oesapay K.,Oesapay G.,Yuan J.,Tang Y.-Q.,
- Title:A cyclic antimicrobial peptide produced in primate leukocytes by the ligation of two truncated alpha-defensins.
- Journal:Science, 1999, 286, 498-502 [MEDLINE:99453140]
- [2] Nguyen T.,Hong T.,Aleshina G.,Kokryakov V.N.,Leonova L.,
- Title:Circular minidefensins and posttranslational generation of molecular diversity.
- Journal:J. Leukoc. Biol., 2001, 70, 461-464 [PubMed:11527997]
- [3] Cole T.,Yuan J.,Tang Y.-Q.,Tran P.A.,Tran D.,
- Title:Homodimeric theta-defensins from rhesus macaque leukocytes: isolation, synthesis, antimicrobial activities, and bacterial binding properties of the cyclic peptides.
- Journal:J. Biol. Chem., 2002, 277, 3079-3084 [PubMed:11675394]
Comments
- Comments
No comments found on LAMP database