Record in detail
General Info
- lamp_id:L03A000339
- Name:CIRA_CHAPA
- FullName:Circulin-A
- Source:Chassalia parviflora
- Mass:3175.7 Da
- Sequence Length:30 aa
- Isoelectric Point:8.11
- Activity:Antimicrobial
- Sequence
SCVWIPCISAALGCSCKNKVCYRNGIPCGE - Function:Probably participates in a plant defense mechanism. Has antibiotic activity. Inhibits the cytopathic effects and replication of the human immunodeficiency virus. Active against the Gram-positive S.aureus with a minimum inhibition concentration of approximately 0.2 microM. Relatively ineffective against Gram-negative bacteria such as E.coli and P.aeruginosa.
Cross-Linking
- Cross-linking
- 1 Database:Uniprot P56871
- 2 Database:AMD CIRA_CHAPA
Top similar AMPs
- Top similar AMPs on LAMP
- 1. L03A000339 From 1 To 30 E-value: 0.000000000003 Score: 62.4
SCVWIPCISAALGCSCKNKVCYRNGIPCGE - 2. L02A001025 From 1 To 30 E-value: 0.00000000005 Score: 58.2
SCVFIPCISAAIGCSCKNKVCYRNGFPCGE - 3. L13A027860 From 4 To 30 E-value: 0.0000000002 Score: 56.2
SCVWIPCISAALGCSCKNKVCYRNGIP - 4. L02A001022 From 1 To 31 E-value: 0.0000000004 Score: 55.1
SCVFIPCISAAIGCSCKNKVCYRNGVIPCGE - 5. L02A001024 From 1 To 30 E-value: 0.0000000007 Score: 54.3
SCVFIPCLTTVAGCSCKNKVCYRNGIPCGE
Activity
- Antibacterial Activities
No MICs found on LAMP database
Toxicity
- Toxicity
No toxicity records found on LAMP database
Reference
- Reference
- [1] Suzuki T.,Hayashi K.,Suketa Y.,Fujikawa K.,
- Title:Chemical structure of circulin A.
- Journal:Experientia, 1965, 21, 307-308 [MEDLINE:67017287]
- [2] Kashman Y.,Parson I.C.,Henderson L.E.,Sowder R.C. II,Gustafson K.R.,
- Title:Circulins A and B: novel HIV-inhibitor macrocyclic peptide from tropical tree Chassalia parvifolia.
- Journal:J. Am. Chem. Soc., 1994, 116, 9337-9338 [DOI:10.1021/ja00099a064]
- [3] Pannell L.K.,Gustafson K.R.,Derua R.,
- Title:Analysis of the disulfide linkage pattern in circulin A and B, HIV-inhibitory macrocyclic peptides.
- Journal:Biochem. Biophys. Res. Commun., 1996, 228, 632-638 [MEDLINE:97079229]
- [4] Chiu K.-W.,Yang J.-L.,Lu Y.-A.,Tam J.P.,
- Title:An unusual structural motif of antimicrobial peptides containing end-to-end macrocycle and cystine-knot disulfides.
- Journal:Proc. Natl. Acad. Sci. U.S.A., 1999, 96, 8913-8918 [MEDLINE:99362685]
- [5] Casas-Finet J.R.,Boyd M.R.,Gustafson K.R.,Koltay A.,Daly N.L.,
- Title:Solution structure by NMR of circulin A: a macrocyclic knotted peptide having anti-HIV activity.
- Journal:J. Mol. Biol., 1999, 285, 333-345 [MEDLINE:99096927]
Comments
- Comments
No comments found on LAMP database