Record in detail


General Info

  • lamp_id:L04ABAC025
  • Name:LANA_STRMU
  • FullName:Lantibiotic mutacin-2
  • Source:Streptococcus mutans
  • Mass:3157.6 Da
  • Sequence Length:25 aa
  • Isoelectric Point:8.53
  • Activity:Antimicrobial
  • Sequence
        NRWWQGVVPTVSYECRMNSWQHVFF
  • Function:Lanthionine-containing peptide antibiotic (lantibiotic) active on Gram-positive bacteria including M.luteus, S.aureus, Streptococcus, P.micros, P.acidilactici, C.sporogenes, C.diphtheriae, A.viscosus, G.vaginalis, P.acnes, L.monocytogenes and M.smegmatis, and Gram-negative bacteria including C.jejuni, H.pylori and N.gonorrhoeae. Transiently and partially depolarizes the transmembrane electrical potential and pH gradient of susceptible cells, inhibits the uptake of amino acids and depletes the intracellular ATP pool.

Cross-Linking

  •   Cross-linking
  •   1  Database:Uniprot  P84110
  •   2  Database:BAC  BAC025

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L04ABAC025    From 1 To 25 E-value: 0.0000000002 Score: 56.6
        NRWWQGVVPTVSYECRMNSWQHVFF
  • 2. L12A08794|    From 27 To 50 E-value: 0.0000000002 Score: 56.2
        NRWWQGVVPTVSYECRMNSWQHVF
  • 3. L01A000543    From 1 To 24 E-value: 0.0000000008 Score: 54.3
        NRWWQGVVPTVSYECRMNSWQHVF
  • 4. L12A06745|    From 27 To 50 E-value: 0.00000002 Score: 49.7
        SRWWQGVLPTVSHECRMNSFQHIF
  • 5. L12A06286|    From 34 To 52 E-value: 0.0003 Score: 35.4
        GVIQTISHECRMNSWQFLF

Structure

  •   Domains
  •   1  Name:Lantibiotic_typ-A    Interpro Link:IPR007682
  •   Structures

        No structs found on LAMP database

Activity

  •   Antibacterial Activities

    •     No MICs found on LAMP database

Toxicity

  •   Toxicity

    •     No toxicity records found on LAMP database

Reference

  •   Reference
  •   [1]  Miller E.J.,Caufield P.W.,Novak J.,
  •   Title:Isolation and biochemical characterization of a novel lantibiotic mutacin from Streptococcus mutans.
  •   Journal:J. Bacteriol., 1994, 176, 4316-4320  [MEDLINE:94292461]
  •   [2]  Schilling K.M.,Konings W.N.,Driessen A.J.M.,Novak J.,Chikindas M.L.,
  •   Title:Mutacin II, a bactericidal lantibiotic from Streptococcus mutans.
  •   Journal:Antimicrob. Agents Chemother., 1995, 39, 2656-2660  [MEDLINE:96161276]
  •   [3]  Morrison K.,Barnes S.,Caufield P.W.,Kirk M.,Novak J.,
  •   Title:Detection of modified amino acids in lantibiotic peptide mutacin II by chemical derivation and electrospray ionization-mass spectroscopic analysis.
  •   Journal:Anal. Biochem., 1996, 236, 358-360  [MEDLINE:96304760]
  •   [4]  Caufield P.W.,Novak J.,Woodruff W.A.,
  •   Title:Sequence analysis of mutA and mutM genes involved in the biosynthesis of the lantibiotic mutacin II in Streptococcus mutans.
  •   Journal:Gene, 1998, 206, 37-43  [MEDLINE:98121310]
  •   [5]  Qi F.,Barnes S.,Kirk M.,Novak J.,Chen P.,
  •   Title:Structure-activity study of the lantibiotic mutacin II from Streptococcus mutans T8 by a gene replacement strategy.
  •   Journal:Appl. Environ. Microbiol., 1998, 64, 2335-2340  [MEDLINE:98320567]
  •   [6]  Barnes S.,Kirk M.,Novak J.,Chen P.,Krull R.E.,
  •   Title:Biochemical structural analysis of the lantibiotic mutacin II.
  •   Journal:J. Biol. Chem., 2000, 275, 15845-15850  [MEDLINE:20283611]
  •   [7]  Caufield P.W.,Krull R.E.,Novak J.,Qi F.,Chen P.,
  •   Title:Effect of amino acid substitutions in conserved residues in the leader peptide on biosynthesis of the lantibiotic mutacin II.
  •   Journal:FEMS Microbiol. Lett., 2001, 195, 139-144  [MEDLINE:21100277]
  •   [8]  Lavoie M.C.,LaPointe G.,Morency H.,Nicolas G.,
  •   Title:Mutacin H-29B is identical to mutacin II (J-T8).
  •   Journal:BMC Microbiol., 2006, 6, 36-36  [PubMed:16626493]

Comments

  •   Comments

    •     No comments found on LAMP database



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