Record in detail


General Info

  • lamp_id:L04ABAC038
  • Name:LANA2_LACLL
  • FullName:Lantibiotic lacticin 3147 A2
  • Source:Lactococcus lactis subsp. lactis
  • Mass:2987.4 Da
  • Sequence Length:29 aa
  • Isoelectric Point:8.51
  • Activity:Antimicrobial
  • Sequence
        TTPATPAISILSAYISTNTCPTTKCTRAC
  • Function:Lanthionine-containing peptide antibiotic (lantibiotic) active on Gram-positive bacteria. The bactericidal activity of lantibiotics is based on depolarization of energized bacterial cytoplasmic membranes, initiated by the formation of aqueous transmembrane pores. When present individually lacticin 3147 A2 exhibits weak activity towards L.lactis strain AM2 and L.lactis strain HP, and no activity towards L.lactis strain IFPL359, but when combined with lacticin 3147 A1 it displays strong activity towards all three strains.

Cross-Linking

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L12A07801|    From 37 To 65 E-value: 0.00000000002 Score: 59.3
        TTPATPAISILSAYISTNTCPTTKCTRAC
  • 2. L04ABAC038    From 1 To 29 E-value: 0.0000000003 Score: 55.5
        TTPATPAISILSAYISTNTCPTTKCTRAC
  • 3. L12A08151|    From 51 To 67 E-value: 0.004 Score: 32
        GYISNQTCPTTACTRAC
  • 4. L04ABAC195    From 16 To 32 E-value: 0.01 Score: 30.8
        GYISNQTCPTTACTRAC
  • 5. L11A007389    From 10 To 26 E-value: 0.011 Score: 30.4
        GYISNQTCPTTACTRAC

Structure

  •   Domains

    •     No domains found on LAMP database
  •   Structures

        No structs found on LAMP database

Activity

  •   Antibacterial Activities

    •     No MICs found on LAMP database

Toxicity

  •   Toxicity

    •     No toxicity records found on LAMP database

Reference

  •   Reference
  •   [1]  Venter J.C.,Richardson D.R.,Weidman J.F.,Hill C.,Dougherty B.A.,
  •   Title:Sequence and analysis of the 60 kb conjugative, bacteriocin-producing plasmid pMRC01 from Lactococcus lactis DPC3147.
  •   Journal:Mol. Microbiol., 1998, 29, 1029-1038  [MEDLINE:99000510]
  •   [2]  Jung G.,Sahl H.-G.,Josten M.,Jack R.W.,Ryan M.P.,
  •   Title:Extensive post-translational modification, including serine to D-alanine conversion, in the two-component lantibiotic, lacticin 3147.
  •   Journal:J. Biol. Chem., 1999, 274, 37544-37550  [MEDLINE:20076413]
  •   [3]  Nissen-Meyer J.,Hauge H.H.,Kok J.,Buist G.,Martinez-Cuesta M.C.,
  •   Title:Biological and molecular characterization of a two-peptide lantibiotic produced by Lactococcus lactis IFPL105.
  •   Journal:J. Appl. Microbiol., 2000, 89, 249-260  [MEDLINE:20430196]
  •   [4]  Hill C.,Cotter P.D.,Carpenter M.R.,Sprules T.,Martin N.I.,
  •   Title:Structural characterization of lacticin 3147, a two-peptide lantibiotic with synergistic activity.
  •   Journal:Biochemistry, 2004, 43, 3049-3056  [PubMed:15023056]

Comments

  •   Comments

    •     No comments found on LAMP database



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