Record in detail


General Info

  • lamp_id:L04ABAC143
  • Name:Q47765_ENTFL
  • FullName:
  • Source:Enterococcus faecalis
  • Mass:7167.5 Da
  • Sequence Length:70 aa
  • Isoelectric Point:10.83
  • Activity:Antimicrobial
  • Sequence
        MAKEFGIPAAVAGTVLNVVEAGGWVTTIVSILTAVGSGGLSLLAAAGRESIKAYLKKEIKKKGKRAVIAW
  • Function:null

Cross-Linking

  •   Cross-linking
  •   1  Database:DBAASP  6694
  •   2  Database:dbAMP  dbAMP_06258
  •   3  Database:DRAMP  DRAMP18265
  •   4  Database:Uniprot  Q47765
  •   5  Database:BAC  BAC143

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L04ABAC143    From 1 To 70 E-value: 3e-33 Score: 132
        MAKEFGIPAAVAGTVLNVVEAGGWVTTIVSILTAVGSGGLSLLAAAGRESIKAYLKKEIKKKGKRAVIAW
  • 2. L11A006698    From 1 To 70 E-value: 5e-33 Score: 131
        MAKEFGIPAAVAGTVLNVVEAGGWVTTIVSILTAVGSGGLSLLAAAGRESIKSYLKKEIKKKGKRAVIAW
  • 3. L02A000929    From 1 To 70 E-value: 6e-33 Score: 130
        MAKEFGIPAAVAGTVINVVEAGGWVTTIVSILTAVGSGGLSLLAAAGRESIKAYLKKEIKKKGKRAVIAW
  • 4. L11A006699    From 2 To 70 E-value: 1e-32 Score: 129
        AKEFGIPAAVAGTVLNVVEAGGWVTTIVSILTAVGSGGLSLLAAAGRESIKAYLKKEIKKKGKRAVIAW
  • 5. L11A006695    From 1 To 70 E-value: 2e-32 Score: 129
        MAKEFGIPAAVAKTVLNVVEAGGWVTTIVSILTAVGSGGLSLLAAAGRESIKAYLKKEIKKKGKRAVIAW

Structure

  •   Domains
  •   1  Name:Bacteriocin_AS48    Interpro Link:IPR009086
  •   2  Name:Bacteriocin_uberolysin    Interpro Link:IPR020038
  •   Structures
  •   1
    PDB:1E68
    Method:NMR
    Chains:A=36-105
  •   2
    PDB:1O82
    Method:X-ray
    Chains:A/B/C/D=36-105
  •   3
    PDB:1O83
    Method:X-ray
    Chains:A/B/C/D=36-105
  •   4
    PDB:1O84
    Method:X-ray
    Chains:A/B=36-105

Activity

  •   Antibacterial Activities

    •     No MICs found on LAMP database

Toxicity

  •   Toxicity

    •     No toxicity records found on LAMP database

Reference

  •   Reference
  •   [1]  Van Beeumen J.,Samyn B.,Galvez A.,Maqueda M.,Martinez-Bueno M.,
  •   Title:Determination of the gene sequence and the molecular structure of the enterococcal peptide antibiotic AS-48.
  •   Journal:J. Bacteriol., 1994, 176, 6334-6339  [MEDLINE:95014079]
  •   [2]  Galvez A.,Maqueda M.,Devreese B.,Martinez-Bueno M.,Samyn B.,
  •   Title:The cyclic structure of the enterococcal peptide antibiotic AS-48.
  •   Journal:FEBS Lett., 1994, 352, 87-90  [MEDLINE:95010683]
  •   [3]  Maqueda M.,Coyette J.,Galvez A.,Valdivia E.,Martinez-Bueno M.,
  •   Title:Analysis of the gene cluster involved in production and immunity of the peptide antibiotic AS-48 in Enterococcus faecalis.
  •   Journal:Mol. Microbiol., 1998, 27, 347-358  [MEDLINE:98143421]
  •   [4]  Valdivia E.,Galvez A.,Bruix M.,Langdon G.M.,Gonzalez C.,
  •   Title:Bacteriocin AS-48, a microbial cyclic polypeptide structurally and functionally related to mammalian NK-lysin.
  •   Journal:Proc. Natl. Acad. Sci. U.S.A., 2000, 97, 11221-11226  [MEDLINE:20481889]
  •   [5]  Maqueda M.,Valdivia E.,Galvez A.,Martinez-Ripoll M.,Sanchez-Barrena M.J.,
  •   Title:Structure of bacteriocin AS-48: from soluble state to membrane bound state.
  •   Journal:J. Mol. Biol., 2003, 334, 541-549  [PubMed:14623193]

Comments

  •   Comments

    •     No comments found on LAMP database



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