Record in detail
General Info
- lamp_id:L05A0DEF89
- Name:DEFB1_CHILA
- FullName:Beta-defensin 1
- Source:Chinchilla lanigera
- Mass:5130.1 Da
- Sequence Length:45 aa
- Isoelectric Point:11.4
- Activity:Antimicrobial
- Sequence
GIINTIQRYFCRVRGGRCAALTCLPRETQIGRCSVKGRKCCRTRK - Function:Has antibacterial activity against Gram-positive bacterium S.pneumoniae Serotype 14. Is also active against Gram-negative bacteria M.catarrhalis 1857, and non-typeable H.influenzae strains 86-028NP and 1128. Has antifungal activity against C.albicans. May have a role in maintaining sterility in the middle ear.
Cross-Linking
- Cross-linking
- 1 Database:DBAASP 1481
- 2 Database:dbAMP dbAMP_03006
- 3 Database:SATPdb satpdb13003
- 4 Database:Uniprot P83943
- 5 Database:DEF DEF89
Top similar AMPs
- Top similar AMPs on LAMP
- 1. L03A000248 From 23 To 67 E-value: 1e-20 Score: 90.5
GIINTIQRYFCRVRGGRCAALTCLPRETQIGRCSVKGRKCCRTRK - 2. L05A0DEF89 From 1 To 45 E-value: 3e-20 Score: 89
GIINTIQRYFCRVRGGRCAALTCLPRETQIGRCSVKGRKCCRTRK - 3. L01A003036 From 1 To 45 E-value: 4e-16 Score: 75.1
GIINTLQKYYCRVRGGRCAVLTCLPKEEQIGKCSTRGRKCCRRKK - 4. L03A000252 From 23 To 67 E-value: 6e-16 Score: 74.3
GIINTLQKYYCRVRGGRCAVLSCLPKEEQIGKCSTRGRKCCRRKK - 5. L03A000247 From 23 To 67 E-value: 6e-16 Score: 74.3
GIINTLQKYYCRVRGGRCAVLSCLPKEEQIGKCSTRGRKCCRRKK
Structure
- Domains
- 1 Name:Defensin_beta-typ Interpro Link:IPR001855
- Structures
No structs found on LAMP database
Activity
- Antibacterial Activities
No MICs found on LAMP database
Toxicity
- Toxicity
No toxicity records found on LAMP database
Reference
- Reference
- [1] Bakaletz L.O.,Munson R.S. Jr.,Bevins C.L.,Wilk D.,Harris R.H.,
- Title:Identification and characterization of mucosal antimicrobial peptides expressed by the chinchilla (Chinchilla lanigera) airway.
- Journal:J. Biol. Chem., 2004, 279, 20250-20256 [PubMed:14996845]
Comments
- Comments
No comments found on LAMP database