Record in detail


General Info

  • lamp_id:L05A0DEF92
  • Name:RTD1B_MACMU
  • FullName:Rhesus theta defensin-1/2 subunit B
  • Source:Macaca mulatta
  • Mass:1419.8 Da
  • Sequence Length:12 aa
  • Isoelectric Point:9
  • Activity:Antimicrobial
  • Sequence
        RCLCRRGVCQLL
  • Function:RTD-1 and RTD-2 have similar antimicrobial activities against the Gram-positive bacteria S.aureus 502A and L.monocytogenes, the Gram-negative bacterium S.typhimurium, and the fungi C.albicans 16820 and C.neoformans 271A. RTD-2 is 2-3-fold less active than RTD-1 against E.coli ML35.

Cross-Linking

  •   Cross-linking
  •   1  Database:Uniprot  P82271
  •   2  Database:DEF  DEF92

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L01A000834    From 65 To 76 E-value: 0.031 Score: 27.7
        RCLCRRGVCQLL
  • 2. L12A09188|    From 65 To 76 E-value: 0.065 Score: 26.9
        RCVCRRGVCQLL
  • 3. L12A09187|    From 65 To 76 E-value: 0.068 Score: 26.9
        RCFCRRGVCQLL
  • 4. L05A0DEF92    From 1 To 12 E-value: 0.14 Score: 25.8
        RCLCRRGVCQLL
  • 5. L01A000837    From 48 To 59 E-value: 2.1 Score: 21.9
        RCICGRGICRLL

Structure

  •   Domains
  •   1  Name:Alpha-defensin    Interpro Link:IPR016327
  •   2  Name:Defensin_propep    Interpro Link:IPR002366
  •   Structures

        No structs found on LAMP database

Activity

  •   Antibacterial Activities

    •     No MICs found on LAMP database

Toxicity

  •   Toxicity

    •     No toxicity records found on LAMP database

Reference

  •   Reference
  •   [1]  Tran D.,Oesapay K.,Oesapay G.,Yuan J.,Tang Y.-Q.,
  •   Title:A cyclic antimicrobial peptide produced in primate leukocytes by the ligation of two truncated alpha-defensins.
  •   Journal:Science, 1999, 286, 498-502  [MEDLINE:99453140]
  •   [2]  Nguyen T.,Hong T.,Aleshina G.,Kokryakov V.N.,Leonova L.,
  •   Title:Circular minidefensins and posttranslational generation of molecular diversity.
  •   Journal:J. Leukoc. Biol., 2001, 70, 461-464  [PubMed:11527997]
  •   [3]  Cole T.,Yuan J.,Tang Y.-Q.,Tran P.A.,Tran D.,
  •   Title:Homodimeric theta-defensins from rhesus macaque leukocytes: isolation, synthesis, antimicrobial activities, and bacterial binding properties of the cyclic peptides.
  •   Journal:J. Biol. Chem., 2002, 277, 3079-3084  [PubMed:11675394]

Comments

  •   Comments

    •     No comments found on LAMP database



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