Record in detail


General Info

  • lamp_id:L06AT00059
  • Name:THNB_HORVU
  • FullName:Beta-hordothionin
  • Source:Hordeum vulgare
  • Mass:4926.8 Da
  • Sequence Length:45 aa
  • Isoelectric Point:10.05
  • Activity:Antimicrobial
  • Sequence
        KSCCRSTLGRNCYNLCRVRGAQKLCANACRCKLTSGLKCPSSFPK
  • Function:Thionins are small plant proteins which are toxic to animal cells. They seem to exert their toxic effect at the level of the cell membrane. Their precise function is not known.

Cross-Linking

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L06AT00059    From 1 To 45 E-value: 3e-20 Score: 88.6
        KSCCRSTLGRNCYNLCRVRGAQKLCANACRCKLTSGLKCPSSFPK
  • 2. L06AT00056    From 1 To 45 E-value: 1e-17 Score: 80.1
        KSCCKSTLGRNCYNLCRARGAQKLCANVCRCKLTSGLSCPKDFPK
  • 3. L12A05349|    From 1 To 45 E-value: 6e-17 Score: 77.8
        KSCCRSTLGRNCYNLCRVRGAQKLCAGVCRCKLTSSGKCPTGFPK
  • 4. L13A025115    From 1 To 45 E-value: 1e-16 Score: 77
        KSCCRSTLGRNCYNLCRARGAQKLCAGVCRCKISSGLSCPKGFPK
  • 5. L06AT00057    From 1 To 45 E-value: 2e-16 Score: 76.3
        KSCCRTTLGRNCYNLCRSRGAQKLCSTVCRCKLTSGLSCPKGFPK

Structure

  •   Domains
  •   1  Name:Thionin    Interpro Link:IPR001010
  •   Structures
  •   1
    PDB:1WUW

    Method:X-ray
    Chains:A/B=28-72

Activity

  •   Antibacterial Activities

  •     No MICs found on LAMP database

Toxicity

  •   Toxicity

  •     No toxicity records found on LAMP database

Reference

  •   Reference
  •   [1]  Garcia-Olmedo F.,Ponz F.,Paz-Ares J.,Royo J.,Hernandez-Lucas C.,
  •   Title:Polyadenylation site heterogeneity in mRNA encoding the precursor of the barley toxin beta-hordothionin.
  •   Journal:FEBS Lett., 1986, 200, 103-106  [:]
  •   [2]  Rasmussen C.E.,Rasmussen S.K.,
  •   Title:Full-length cDNA clone encoding barley toxin beta-hordothionin.
  •   Journal:Plant Mol. Biol., 1993, 21, 579-579  [:]
  •   [3]  Stec B.,Suh S.W.,Teeter M.M.,Kim E.,Johnson K.A.,
  •   Title:Crystal structure of alpha-hordothionin at 1.9 Angstrom resolution.
  •   Journal:FEBS Lett., 2005, 579, 2301-2306  [PubMed:15848162]

Comments

  •   Comments

  •     No comments found on LAMP database



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