Record in detail


General Info

  • lamp_id:L07APD0013
  • Name:TRFL_HUMAN
  • FullName:Lactotransferrin
  • Source:Homo sapiens
  • Mass:1530.8 Da
  • Sequence Length:11 aa
  • Isoelectric Point:12.81
  • Activity:Antimicrobial
  • Sequence
        FQWQRNIRKVR
  • Function:Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate.

Cross-Linking

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L01A003980    From 1 To 11 E-value: 0.18 Score: 25
        FQWQRNIRKVR
  • 2. L07APD0013    From 1 To 11 E-value: 0.18 Score: 25
        FQWQRNIRKVR
  • 3. L11A001405    From 6 To 16 E-value: 0.2 Score: 25
        FQWQRNMRKVR
  • 4. L13A018936    From 4 To 14 E-value: 0.21 Score: 25
        FQWQRNMRKVR
  • 5. L02A000780    From 21 To 31 E-value: 0.21 Score: 25
        FQWQRNMRKVR

Structure

  •   Domains
  •   1  Name:Peptidase_S60    Interpro Link:IPR001156
  •   2  Name:Transferrin    Interpro Link:IPR016357
  •   3  Name:Transferrin_Fe_BS    Interpro Link:IPR018195
  •   Structures
  •   1
    PDB:1B0L

    Method:X-ray
    Chains:A=20-710
  •   2
    PDB:1BKA

    Method:X-ray
    Chains:A=20-710
  •   3
    PDB:1CB6

    Method:X-ray
    Chains:A=20-710
  •   4
    PDB:1DSN

    Method:X-ray
    Chains:A=21-352
  •   5
    PDB:1EH3

    Method:X-ray
    Chains:A=21-348
  •   6
    PDB:1FCK

    Method:X-ray
    Chains:A=21-710
  •   7
    PDB:1H43

    Method:X-ray
    Chains:A=21-352
  •   8
    PDB:1H44

    Method:X-ray
    Chains:A=21-352
  •   9
    PDB:1H45

    Method:X-ray
    Chains:A=21-352
  •   10
    PDB:1HSE

    Method:X-ray
    Chains:A=21-353
  •   11
    PDB:1L5T

    Method:X-ray
    Chains:A/B=21-351
  •   12
    PDB:1LCF

    Method:X-ray
    Chains:A=20-710
  •   13
    PDB:1LCT

    Method:X-ray
    Chains:A=21-352
  •   14
    PDB:1LFG

    Method:X-ray
    Chains:A=20-710
  •   15
    PDB:1LFH

    Method:X-ray
    Chains:A=20-710
  •   16
    PDB:1LFI

    Method:X-ray
    Chains:A=20-710
  •   17
    PDB:1LGB

    Method:X-ray
    Chains:C=110-268
  •   18
    PDB:1N76

    Method:X-ray
    Chains:A=21-710
  •   19
    PDB:1SQY

    Method:X-ray
    Chains:A=20-710
  •   20
    PDB:1U62

    Method:NMR
    Chains:A=39-49
  •   21
    PDB:1VFD

    Method:X-ray
    Chains:A=22-349
  •   22
    PDB:1VFE

    Method:X-ray
    Chains:A=22-352
  •   23
    PDB:1XV4

    Method:NMR
    Chains:A=39-49
  •   24
    PDB:1XV7

    Method:NMR
    Chains:A=39-49
  •   25
    PDB:1Z6V

    Method:NMR
    Chains:A=21-67
  •   26
    PDB:1Z6W

    Method:NMR
    Chains:A=21-67
  •   27
    PDB:2BJJ

    Method:X-ray
    Chains:X=21-710
  •   28
    PDB:2DP4

    Method:X-ray
    Chains:I=528-535
  •   29
    PDB:2GMC

    Method:NMR
    Chains:A=39-49
  •   30
    PDB:2GMD

    Method:NMR
    Chains:A=39-49
  •   31
    PDB:2HD4

    Method:X-ray
    Chains:B=528-535
  •   32
    PDB:2PMS

    Method:X-ray
    Chains:A/B=21-362

Activity

  •   Antibacterial Activities

  •     No MICs found on LAMP database

Toxicity

  •   Toxicity

  •     No toxicity records found on LAMP database

Reference

  •   Reference
  •   [1]  Montreuil J.,Spik G.,Jolles J.,Mazurier J.,Metz-Boutigue M.-H.,
  •   Title:The present state of the human lactotransferrin sequence. Study and alignment of the cyanogen bromide fragments and characterization of N- and C-terminal domains.
  •   Journal:Biochim. Biophys. Acta, 1981, 670, 243-254  [MEDLINE:82046817]
  •   [2]  Montreuil J.,Spik G.,Mazurier J.,Jolles J.,Metz-Boutigue M.-H.,
  •   Title:An 88 amino acid long C-terminal sequence of human lactotransferrin.
  •   Journal:FEBS Lett., 1982, 142, 107-110  [MEDLINE:82262043]
  •   [3]  Legrand D.,Schoentgen F.,Mazurier J.,Jolles J.,Metz-Boutigue M.-H.,
  •   Title:Human lactotransferrin: amino acid sequence and structural comparisons with other transferrins.
  •   Journal:Eur. J. Biochem., 1984, 145, 659-676  [MEDLINE:85076667]
  •   [4]  Benz E.J. Jr.,Wei X.,Rado T.A.,
  •   Title:Isolation of lactoferrin cDNA from a human myeloid library and expression of mRNA during normal and leukemic myelopoiesis.
  •   Journal:Blood, 1987, 70, 989-993  [MEDLINE:88001031]
  •   [5]  Baker E.N.,Rice D.W.,Norris G.E.,Baker H.M.,Anderson B.F.,
  •   Title:Structure of human lactoferrin: crystallographic structure analysis and refinement at 2.8-A resolution.
  •   Journal:J. Mol. Biol., 1989, 209, 711-734  [MEDLINE:90064528]
  •   [6]  Pieper F.R.,de Boer H.A.,Woloshuk S.L.,Rey M.W.,
  •   Title:Complete nucleotide sequence of human mammary gland lactoferrin.
  •   Journal:Nucleic Acids Res., 1990, 18, 5288-5288  [MEDLINE:90384839]
  •   [7]  Yoshikawa M.,Chiba H.,Iio K.,Tani F.,
  •   Title:Isolation and characterization of opioid antagonist peptides derived from human lactoferrin.
  •   Journal:Agric. Biol. Chem., 1990, 54, 1803-1810  [MEDLINE:91166929]
  •   [8]  Ogden J.E.,Powell M.J.,
  •   Title:Nucleotide sequence of human lactoferrin cDNA.
  •   Journal:Nucleic Acids Res., 1990, 18, 4013-4013  [MEDLINE:90326549]
  •   [9]  Panella T.,Walmer D.,Yang N.,Liu Y.,Teng C.T.,
  •   Title:Differential molecular mechanism of the estrogen action that regulates lactoferrin gene in human and mouse.
  •   Journal:Mol. Endocrinol., 1992, 6, 1969-1981  [MEDLINE:93125571]
  •   [10]  Sato I.
  •   Title:Characterization of the 84-kDa protein with ABH activity in human seminal plasma.
  •   Journal:Nihon Hoigaku Zasshi, 1995, 49, 281-293  [PubMed:8551695]
  •   [11]  Baker E.N.,Anderson B.F.,Haridas M.,
  •   Title:Structure of human diferric lactoferrin refined at 2.2-A resolution.
  •   Journal:Acta Crystallogr. D, 1995, 51, 629-646  [PubMed:15299793]
  •   [12]  Tweedie J.W.,Shewry S.C.,Bland T.,Anderson B.F.,Nicholson H.,
  •   Title:Mutagenesis of the histidine ligand in human lactoferrin: iron binding properties and crystal structure of the histidine-253-->methionine mutant.
  •   Journal:Biochemistry, 1997, 36, 341-346  [MEDLINE:97156796]
  •   [13]  Ahmed M.N.,Han L.,Obrian G.,Sommer J.R.,Klintworth G.K.,
  •   Title:Familial subepithelial corneal amyloidosis (gelatinous drop-like corneal dystrophy): exclusion of linkage to lactoferrin gene.
  •   Journal:Mol. Vis., 1998, 4, 31-32  [MEDLINE:99091914]
  •   [14]  Baker E.N.,Thomas D.H.,Norris G.E.,Anderson B.F.,Jameson G.B.,
  •   Title:Structure of human apolactoferrin at 2.0-A resolution. Refinement and analysis of ligand-induced conformational change.
  •   Journal:Acta Crystallogr. D, 1998, 54, 1319-1335  [MEDLINE:99192677]
  •   [15]  Baker E.N.,Jameson G.B.,Shewry S.C.,Baker H.M.,Sun X.L.,
  •   Title:Structure of recombinant human lactoferrin expressed in Aspergillus awamori.
  •   Journal:Acta Crystallogr. D, 1999, 55, 403-407  [MEDLINE:99190892]
  •   [16]  Huan L.D.,Chen X.Z.,Cheng H.,
  •   Title:cDNA cloning and sequence analysis of human lactoferrin.
  •   Journal:Sheng Wu Gong Cheng Xue Bao, 2001, 17, 385-387  [PubMed:11702692]
  •   [17]  Petty S.,Fink D.L.,Shewry S.C.,Qiu J.,Hendrixson D.R.,
  •   Title:Human milk lactoferrin is a serine protease that cleaves Haemophilus surface proteins at arginine-rich sites.
  •   Journal:Mol. Microbiol., 2003, 47, 607-617  [PubMed:12535064]
  •   [18]  Fierro J.F.,Sanchez M.,Perez-Gil J.,Andres M.T.,Viejo-Diaz M.,
  •   Title:Potassium efflux induced by a new lactoferrin-derived peptide mimicking the effect of native human lactoferrin on the bacterial cytoplasmic membrane.
  •   Journal:Biokhimiia, 2003, 68, 217-227  [MEDLINE:22580654]
  •   [19]  
  •   Title:The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
  •   Journal:Genome Res., 2004, 14, 2121-2127  [PubMed:15489334]
  •   [20]  Yu J.,Possemato A.,Zeng Q.,Guo A.,Rikova K.,
  •   Title:Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer.
  •   Journal:Cell, 2007, 131, 1190-1203  [PubMed:18083107]
  •   [21]  Addeo F.,Roepstorff P.,Mamone G.,Ferranti P.,Picariello G.,
  •   Title:Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry.
  •   Journal:Proteomics, 2008, 8, 3833-3847  [PubMed:18780401]
  •   [22]  Wang F.,Han G.,Sun D.,Jiang X.,Chen R.,
  •   Title:Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.
  •   Journal:J. Proteome Res., 2009, 8, 651-661  [PubMed:19159218]
  •   [23]  Buerckstuemmer T.,Breitwieser F.P.,Kaupe I.,Planyavsky M.,Burkard T.R.,
  •   Title:Initial characterization of the human central proteome.
  •   Journal:BMC Syst. Biol., 2011, 5, 17-17  [PubMed:21269460]

Comments

  •   Comments

  •     No comments found on LAMP database



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