Record in detail
General Info
- lamp_id:L07APD0027
- Name:CECA_HYACE
- FullName:Cecropin-A
- Source:Hyalophora cecropia
- Mass:4061.9 Da
- Sequence Length:38 aa
- Isoelectric Point:11.18
- Activity:Antimicrobial
- Sequence
KWKLFKKIEKVGQNIRDGIIKAGPAVAVVGQATQIAKG - Function:Cecropins have lytic and antibacterial activity against several Gram-positive and Gram-negative bacteria.
Cross-Linking
- Cross-linking
- 1 Database:dbAMP dbAMP_05495
- 2 Database:SATPdb satpdb22424
- 3 Database:Uniprot P01507
- 4 Database:RAP RAPD0027
Top similar AMPs
- Top similar AMPs on LAMP
- 1. L03A000212 From 27 To 64 E-value: 3e-16 Score: 75.9
KWKLFKKIEKVGQNIRDGIIKAGPAVAVVGQATQIAKG - 2. L07APD0027 From 1 To 38 E-value: 9e-16 Score: 73.9
KWKLFKKIEKVGQNIRDGIIKAGPAVAVVGQATQIAKG - 3. L01A000062 From 1 To 37 E-value: 0.000000000000003 Score: 72
KWKLFKKIEKVGQNIRDGIIKAGPAVAVVGQATQIAK - 4. L11A010351 From 1 To 38 E-value: 0.00000000000001 Score: 70.1
KWKFFKKIERVGQNIRDGIIKAGPAVAVVGQATNIAKG - 5. L11A002257 From 1 To 37 E-value: 0.00000000000002 Score: 69.3
KWKLFKKIEKVGQNIRDGIIKAGPAVAWVGQATQIAK
Structure
- Domains
- 1 Name:Cecropin Interpro Link:IPR000875
- Structures
- 1
PDB:1D9J
Method:NMR
Chains:A=27-34 - 2
PDB:1D9L
Method:NMR
Chains:A=27-34 - 3
PDB:1D9M
Method:NMR
Chains:A=27-34 - 4
PDB:1D9O
Method:NMR
Chains:A=29-34 - 5
PDB:1D9P
Method:NMR
Chains:A=29-34 - 6
PDB:1F0D
Method:NMR
Chains:A=27-34 - 7
PDB:1F0E
Method:NMR
Chains:A=27-34 - 8
PDB:1F0F
Method:NMR
Chains:A=27-34 - 9
PDB:1F0G
Method:NMR
Chains:A=29-34 - 10
PDB:1F0H
Method:NMR
Chains:A=29-34
Activity
- Antibacterial Activities
No MICs found on LAMP database
Toxicity
- Toxicity
No toxicity records found on LAMP database
Reference
- Reference
- [1] Boman H.G.,Bennich H.,Engstroem A.,Hultmark D.,Steiner H.,
- Title:Sequence and specificity of two antibacterial proteins involved in insect immunity.
- Journal:Nature, 1981, 292, 246-248 [MEDLINE:81245158]
- [2] Boman H.G.,Kapur R.,Bennich H.,Engstroem A.,Hultmark D.,
- Title:Insect immunity: isolation and structure of cecropin D and four minor antibacterial components from Cecropia pupae.
- Journal:Eur. J. Biochem., 1982, 127, 207-217 [MEDLINE:83053366]
- [3] Boman H.G.,Xanthopoulos K.G.,Gudmundsson G.H.,Lidholm D.-A.,
- Title:Insect immunity: cDNA clones coding for the precursor forms of cecropins A and D, antibacterial proteins from Hyalophora cecropia.
- Journal:FEBS Lett., 1987, 226, 8-12 [:]
- [4] Bennich H.,Lindeberg G.,Kraulis P.J.,Engstroem A.,Holak T.A.,
- Title:The solution conformation of the antibacterial peptide cecropin A: a nuclear magnetic resonance and dynamical simulated annealing study.
- Journal:Biochemistry, 1988, 27, 7620-7629 [MEDLINE:89088132]
- [5] Boman H.G.,Gan R.,Aasling B.,Lidholm D.-A.,Gudmundsson G.H.,
- Title:The cecropin locus. Cloning and expression of a gene cluster encoding three antibacterial peptides in Hyalophora cecropia.
- Journal:J. Biol. Chem., 1991, 266, 11510-11517 [MEDLINE:91268009]
Comments
- Comments
No comments found on LAMP database