Record in detail


General Info

  • lamp_id:L07APD0033
  • Name:DEFB1_HUMAN
  • FullName:Beta-defensin 1
  • Source:Homo sapiens
  • Mass:4650.3 Da
  • Sequence Length:43 aa
  • Isoelectric Point:8.37
  • Activity:Antimicrobial
  • Sequence
        TPGSPEFDHYNCVSSGGQCLYSACPIFTKIQGTCYRGKAKCCK
  • Function:Has bactericidal activity (By similarity).

Cross-Linking

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L07APD0033    From 1 To 43 E-value: 7e-21 Score: 90.9
        TPGSPEFDHYNCVSSGGQCLYSACPIFTKIQGTCYRGKAKCCK
  • 2. L01A001361    From 33 To 68 E-value: 6e-17 Score: 77.8
        DHYNCVSSGGQCLYSACPIFTKIQGTCYRGKAKCCK
  • 3. L01A001450    From 1 To 36 E-value: 2e-16 Score: 76.3
        DHYNCVSSGGQCLYSACPIFTKIQGTCYRGKAKCCK
  • 4. L12A01057|    From 1 To 36 E-value: 3e-16 Score: 75.5
        DHYNCVSAGGQCLYSACPIFTKIQGTCYRGKAKCCK
  • 5. L12A01063|    From 1 To 36 E-value: 4e-16 Score: 75.1
        DHYNCVSSGGQCLYSACPIFTKIEGTCYRGKAKCCK

Structure

  •   Domains
  •   1  Name:Defensin_beta-typ    Interpro Link:IPR001855
  •   Structures
  •   1
    PDB:1E4S
    Method:NMR
    Chains:A=33-68
  •   2
    PDB:1IJU
    Method:X-ray
    Chains:A/B/C/D=33-68
  •   3
    PDB:1IJV
    Method:X-ray
    Chains:A/B=33-68
  •   4
    PDB:1KJ5
    Method:NMR
    Chains:A=33-68
  •   5
    PDB:2NLB
    Method:X-ray
    Chains:A/B/C/D=33-68
  •   6
    PDB:2NLC
    Method:X-ray
    Chains:A/B/C/D=33-68
  •   7
    PDB:2NLD
    Method:X-ray
    Chains:A/B=33-68
  •   8
    PDB:2NLE
    Method:X-ray
    Chains:A/B=33-68
  •   9
    PDB:2NLF
    Method:X-ray
    Chains:A/B=33-68
  •   10
    PDB:2NLG
    Method:X-ray
    Chains:A/B/C/D=33-68
  •   11
    PDB:2NLH
    Method:X-ray
    Chains:A/B/C/D=33-68
  •   12
    PDB:2NLP
    Method:X-ray
    Chains:A/B/C/D=33-68
  •   13
    PDB:2NLQ
    Method:X-ray
    Chains:A/B/C/D=33-68
  •   14
    PDB:2NLS
    Method:X-ray
    Chains:A=33-68
  •   15
    PDB:2PLZ
    Method:X-ray
    Chains:A=33-67

Activity

  •   Antibacterial Activities

    •     No MICs found on LAMP database

Toxicity

  •   Toxicity

    •     No toxicity records found on LAMP database

Reference

  •   Reference
  •   [1]  Forssmann W.-G.,Schulz-Knappe P.,Maegert H.-J.,Raida M.,Bensch K.W.,
  •   Title:hBD-1: a novel beta-defensin from human plasma.
  •   Journal:FEBS Lett., 1995, 368, 331-335  [MEDLINE:95354864]
  •   [2]  Bentley L.,McCray P.B. Jr.,
  •   Title:Human airway epithelia express a beta-defensin.
  •   Journal:Am. J. Respir. Cell Mol. Biol., 1997, 16, 343-349  [MEDLINE:97224039]
  •   [3]  Ganz T.,Heng H.H.Q.,Zhao C.,Liu L.,
  •   Title:The human beta-defensin-1 and alpha-defensins are encoded by adjacent genes: two peptide families with differing disulfide topology share a common ancestry.
  •   Journal:Genomics, 1997, 43, 316-320  [MEDLINE:97422608]
  •   [4]  Forssmann W.-G.,Conejo-Garcia J.-R.,Kluever E.,Schweimer K.,Bauer F.,
  •   Title:Structure determination of human and murine beta-defensins reveals structural conservation in the absence of significant sequence similarity.
  •   Journal:Protein Sci., 2001, 10, 2470-2479  [MEDLINE:21571984]
  •   [5]  Lubkowski J.,Chertov O.,Hoover D.M.,
  •   Title:The structure of human beta-defensin-1: new insights into structural properties of beta-defensins.
  •   Journal:J. Biol. Chem., 2001, 276, 39021-39026  [MEDLINE:21486418]
  •   [6]  Adermann K.,Forssmann W.-G.,Schulz A.,Kluever E.,
  •   Title:Chemical synthesis of beta-defensins and LEAP-1/hepcidin.
  •   Journal:J. Pept. Res., 2002, 59, 241-248  [MEDLINE:22007551]
  •   [7]  
  •   Title:The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
  •   Journal:Genome Res., 2004, 14, 2121-2127  [PubMed:15489334]

Comments

  •   Comments

    •     No comments found on LAMP database



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