Record in detail


General Info

  • lamp_id:L07APD0108
  • Name:BR2R_PELRI
  • FullName:Brevinin-2R
  • Source:Pelophylax ridibundus
  • Mass:2622.1 Da
  • Sequence Length:25 aa
  • Isoelectric Point:10.35
  • Activity:Antimicrobial
  • Sequence
        KLKNFAIGVAQSLLNKASCKLSGQC
  • Function:Cytotoxic to cancer cells, acts via the activation of the lysosomal-mitochondrial death pathway and autophagy-like cell death. Does not show significant hemolytic activity.

Cross-Linking

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L07APD0108    From 1 To 25 E-value: 0.00000001 Score: 50.1
        KLKNFAIGVAQSLLNKASCKLSGQC
  • 2. L13A011185    From 1 To 25 E-value: 0.00000009 Score: 47.4
        KLKNFAKGVAQSLLNKASCKLSGQC
  • 3. L01A000644    From 5 To 29 E-value: 0.00000009 Score: 47.4
        KLKNFAKGVAQSLLNKASCKLSGQC
  • 4. L01A003436    From 6 To 30 E-value: 0.0000001 Score: 47.4
        KLKNFAKGVAQSLLNKASCKLSGQC
  • 5. L01A000641    From 6 To 34 E-value: 0.00007 Score: 37.7
        KLKNFAKTAGKGVLQSLLNTASCKLSGQC

Structure

  •   Domains
  •   1  Name:Antimicrobial_frog_2    Interpro Link:IPR012521
  •   Structures

        No structs found on LAMP database

Activity

  •   Antibacterial Activities

    •     No MICs found on LAMP database

Toxicity

  •   Toxicity

    •     No toxicity records found on LAMP database

Reference

  •   Reference
  •   [1]  Kadkhoda K.,Halayko A.J.,Klonisch T.,Asoodeh A.,Ghavami S.,
  •   Title:Brevinin-2R semi-selectively kills cancer cells by a distinct mechanism, which involves the lysosomal-mitochondrial death pathway.
  •   Journal:J. Cell. Mol. Med., 2008, 12, 1005-1022  [PubMed:18494941]

Comments

  •   Comments

    •     No comments found on LAMP database



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