Record in detail


General Info

  • lamp_id:L11A003316
  • Name:Tyrocidine A, TA
  • FullName:
  • Source: Bacillus subtilis Bacillus aneurinolyticus Bacillus brevis
  • Mass:1231.4 Da
  • Sequence Length:10 aa
  • Isoelectric Point:6.02
  • Activity:Gram+Gram-ParasiteCancerFungusMammalian Cell
  • Sequence
        fPFfNQYVXL
  • Function:

Cross-Linking

  •   Cross-linking
  •   1  Database:DBAASP  3316

Top similar AMPs

  • Top similar AMPs on LAMP
  • 1. L11A006090    From 1 To 10 E-value: 2.4 Score: 21.6
        FPFFNQYVKL
  • 2. L11A003316    From 1 To 10 E-value: 2.8 Score: 21.2
        FPFFNQYVXL
  • 3. L11A006092    From 1 To 10 E-value: 4.5 Score: 20.4
        FPWFNQYVKL
  • 4. L11A006091    From 1 To 10 E-value: 5.5 Score: 20
        FPWFNQYVXL
  • 5. L11A003321    From 1 To 10 E-value: 6.4 Score: 20
        FPFFNKYVXL

Structure

  •   Domains

    •     No domains found on LAMP database
  •   Structures

        No structs found on LAMP database

Activity

  •   Antibacterial Activities

    •     No MICs found on LAMP database

Toxicity

  •   Toxicity

    •     No toxicity records found on LAMP database

Reference

  •   Reference
  •   [1]  Troskie AM, Rautenbach M, Delattin n, Vosloo JA, Dathe M, Cammue BP, Thevissen K
  •   Title:Synergistic activity of the tyrocidines, antimicrobial cyclodecapeptides from Bacillus aneurinolyticus, with amphotericin B and caspofungin against Candida albicans biofilms
  •   Journal:Antimicrob Agents Chemother, 2014, 58, 3697-3707  [:24752256]
  •   [2]  Rautenbach M, Vlok nM, Stander M, Hoppe HC
  •   Title:Inhibition of malaria parasite blood stages by tyrocidines, membrane-active cyclic peptide antibiotics from Bacillus brevis
  •   Journal:Biochim Biophys Acta, 2007, 1768, 1488-1497  [:17462586]
  •   [3]  Rautenbach M, Troskie AM, Vosloo JA, Dathe ME
  •   Title:Antifungal membranolytic activity of the tyrocidines against filamentous plant fungi
  •   Journal:Biochimie, 2016  [:27328781]
  •   [4]  Wenzel M, Rautenbach M, Vosloo JA, Siersma T, Aisenbrey CHM, Zaitseva E, Laubscher WE, Rensburg W, B
  •   Title:The Multifaceted Antibacterial Mechanisms of the Pioneering Peptide Antibiotics Tyrocidine and Gramicidin S
  •   Journal:MBio, 2018, 9, e00802  [:]
  •   [5]  Marques MA, Citron DM, Wang CC
  •   Title:Development of Tyrocidine A analogues with improved antibacterial activity
  •   Journal:Bioorg Med Chem, 2007, 15, 6667-6677  [:17728134]
  •   [6]  Spathelf BM, Rautenbach M
  •   Title:Anti-listerial activity and structure-activity relationships of the six major tyrocidines, cyclic decapeptides from Bacillus aneurinolyticus
  •   Journal:Bioorg Med Chem, 2009, 17, 5541-5548  [:19586775]

Comments

  •   Comments

    •     No comments found on LAMP database



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