LAMP: A database linking antimicrobial peptide.

Antimicrobial peptides (AMPs) are genetically ancient members of innate defense systems. AMPs are attractive moleculars for clinical development: they can be sythesizes easily, kill drug-resistant bacteria and have a rapid antimicrobial mechanism.

a database linking AMPs, is an integrated open-access database. It has been created with an objective to provide a useful resource and tools for AMP studies. AMPs in LAMP are short, of less than 100 amino acid residues and include natural, synthetic and predicted AMPs. AMPs in LAMP had been grouped into three catalogs by data source: experimental, predicted, and patent. This manually curated database currently holds 5547 AMP sequences, including 3904 natural and 1643 synthetic AMPs. To ensure data quality, we limited the source of information to authoritative public databases and published scientific literature, as well as patents. LAMP also supplies a user-friendly web interface, so that users can easily query and retrieve information on AMPs. A concise navigational interface that contains the database browse, search, tools, statistical information, guide and links, were designed to generate a clearly structured database layout that enables fast and easy navigation. The interface of LAMP is easy to use and allows users to rapidly retrieve data according to their desired search criteria and blast the database for homologous sequences.
A complete documentation of the database features and tools can be accessed from the Guide. The database will be updated monthly with additional sequences. This work has been partly funded by the plan 2012 for Science and technology innovation action of Shanghai, China (grant 12DE1940500) and the ‘Yangtze river delta’ joint scientific and technological project of China (grant 10495810600).

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People involved:

Dr. Qingshan Huang
Mrs. Xiaowei Zhao
Mr. Jinjiang Huang
Mr. Hongyu Wu
Dr. Hairong Lu
Mr. Guodong Li
at SLS, Fudan University