Record in detail
- Enzy_Id:EN22751436
Name:LASA_PSEAE
FullName:Protease lasA,LasA
Producer Organism:Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Sequence Length:418
Mass:45517
Isoelectric Point:9.05
Target:S. aureus
Link:P14789 - Function:Involved in proteolysis and elastolysis. Degradation of elastin is likely to contribute to the pathogenicity of P.aeruginosa.
- Antibacterial Activities
No MICs found on enzybiotics database
- Sequence
- MQHKRSRAMASPRSPFLFVLLALAVGGTANAHDDGLPAFRYSAELLGQLQLPSVALPLND DLFLYGRDAEAFDLEAYLALNAPALRDKSEYLEHWSGYYSINPKVLLTLMVMQSGPLGAP DERALAAPLGRLSAKRGFDAQVRDVLQQLSRRYYGFEEYQLRQAAARKAVGEDGLNAASA ALLGLLREGAKVSAVQGGNPLGAYAQTFQRLFGTPAAELLQPSNRVARQLQAKAALAPPS NLMQLPWRQGYSWQPNGAHSNTGSGYPYSSFDASYDWPRWGSATYSVVAAHAGTVRVLSR CQVRVTHPSGWATNYYHMDQIQVSNGQQVSADTKLGVYAGNINTALCEGGSSTGPHLHFS LLYNGAFVSLQGASFGPYRINVGTSNYDNDCRRYYFYNQSAGTTHCAFRPLYNPGLAL
- Domains
- 1 Name:Dup_hybrid_motif Interpro Link:IPR011055
- 2 Name:Pept_M23A_Blytic Interpro Link:IPR000841
- 3 Name:Peptidase_M23 Interpro Link:IPR016047
- Structures
- Reference
- [1] Warrener P.,Mizoguchi S.D.,Erwin A.L.,Pham X.-Q.T.,Stover C.K.,
- Title:Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen.
- Journal:Nature,2000,(406):959-964 [MEDLINE:20437337]
- [2] Ohman D.E.,Kessler E.,Gustin J.K.,
- Title:A substitution at His-120 in the LasA protease of Pseudomonas aeruginosa blocks enzymatic activity without affecting propeptide processing or extracellular secretion.
- Journal:J. Bacteriol.,1996,(178):6608-6617 [MEDLINE:97086629]
- [3] Ohman D.E.,Olson J.C.,
- Title:Efficient production and processing of elastase and LasA by Pseudomonas aeruginosa require zinc and calcium ions.
- Journal:J. Bacteriol.,1992,(174):4140-4147 [MEDLINE:92283772]
- [4] Galloway D.R.,Peters J.E.,Darzins A.,
- Title:Revised nucleotide sequence of the lasA gene from Pseudomonas aeruginosa PAO1.
- Journal:Nucleic Acids Res.,1990,(18):6444-6444 [MEDLINE:91057149]
- [5] Iglewski B.H.,Schad P.A.,
- Title:Nucleotide sequence and expression in Escherichia coli of the Pseudomonas aeruginosa lasA gene.
- Journal:J. Bacteriol.,1988,(170):2784-2789 [MEDLINE:88227864]