Record in detail
- Enzy_Id:EN22817871
Name:ATL_STAAU
FullName:Bifunctional autolysin,Atl
Producer Organism:Staphylococcus aureus
Sequence Length:1255
Mass:137535
Isoelectric Point:10.09
Target:S. aureus
Link:P0C5Z8 - Function:Endohydrolysis of the di-N-acetylchitobiosyl unit in high-mannose glycopeptides and glycoproteins containing the -[(Man)5(GlcNAc)2]-Asn structure. One N-acetyl-D-glucosamine residue remains attached to the protein; the rest of the oligosaccharide is released intact. Cleaves the peptidoglycan connecting the daughter cells at the end of the cell division cycle, resulting in the separation of the two newly divided cells. Acts as an autolysin in penicillin-induced lysis.
- Antibacterial Activities
No MICs found on enzybiotics database
- Sequence
- MLGVINRMAKKFNYKLPSMVALTLVGSAVTAHQVQAAETTQDQTTNKNVLDSNKVKATTE QAKAEVKNPTQNISGTQVYQDPAIVQPKTANNKTGNAQVSQKVDTAQVNGDTRANQSATT NNTQPVAKSTSTTAPKTNTNVTNAGYSLVDDEDDNSEHQINPELIKSAAKPAALETQYKA AAPKAKTEATPKVTTFSASAQPRSVAATPKTSLPKYKPQVNSSINDYIRKNNLKAPKIEE DYTSYFPKYAYRNGVGRPEGIVVHDTANDRSTINGEISYMKNNYQNAFVHAFVDGDRIIE TAPTDYLSWGVGAVGNPRFINVEIVHTHDYASFARSMNNYADYAATQLQYYGLKPDSAEY DGNGTVWTHYAVSKYLGGTDHADPHGYLRSHNYSYDQLYDLINEKYLIKMGKVAPWGTQF TTTPTTPSKPTTPSKPSTGKLTVAANNGVAQIKPTNSGLYTTVYDKTGKATNEVQKTFAV SKTATLGNQKFYLVQDYNSGNKFGWVKEGDVVYNTAKSPVNVNQSYSIKSGTKLYTVPWG TSKQVAGSVSGSGNQTFKASKQQQIDKSIYLYGSVNGKSGWVSKAYLVDTAKPTPTPIPK PSTPTTNNKLTVSSLNGVAQINAKNNGLFTTVYDKTGKPTKEVQKTFAVTKEASLGGNKF YLVKDYNSPTLIGWVKQGDVIYNNAKSPVNVMQTYTVKPGTKLYSVPWGTYKQEAGAVSG TGNQTFKATKQQQIDKSIYLFGTVNGKSGWVSKAYLAVPAAPKKAVAQPKTAVKAYTVTK PQTTQTVSKIAQVKPNNTGIRASVYEKTAKNGAKYADRTFYVTKERAHGNETYVLLNNTS HNIPLGWFNVKDLNVQNLGKEVKTTQKYTVNKSNNGLSMVPWGTKNQVILTGNNIAQGTF NATKQVSVGKDVYLYGTINNRTGWVNAKDLTAPTAVKPTTSAAKDYNYTYVIKNGNGYYY VTPNSDTAKYSLKAFNEQPFAVVKEQVINGQTWYYGKLSNGKLAWIKSTDLAKELIKYNQ TGMTLNQVAQIQAGLQYKPQVQRVPGKWTDANFNDVKHAMDTKRLAQDPALKYQFLRLDQ PQNISIDKINQFLKGKGVLENQGAAFNKAAQMYGINEVYLISHALLETGNGTSQLAKGAD VVNNKVVTNSNTKYHNVFGIAAYDNDPLREGIKYAKQAGWDTVSKAIVGGAKFIGNSYVK AGQNTLYKMRWNPAHPGTHQYATDVDWANINAKIIKGYYDKIGEVGKYFDIPQYK
- Domains
- 1 Name:Amidase_domain Interpro Link:IPR002502
- 2 Name:Lysozyme_dom_subfam2 Interpro Link:IPR013338
- 3 Name:Mano_Glyc_endo_b_GlcNAc Interpro Link:IPR002901
- Structures
No structs found on enzybiotics database
- Reference
- [1] Daum R.S.,Challapalli M.,Boyle-Vavra S.,
- Title:Resistance to autolysis in vancomycin-selected Staphylococcus aureus isolates precedes vancomycin-intermediate resistance.
- Journal:Antimicrob. Agents Chemother.,2003,(47):2036-2039 [MEDLINE:22645854]
- [2] Okagaki C.,Yamada M.,Yasojima A.,Oshida T.,Takano M.,
- Title:Modification of autolysis by synthetic peptides derived from the presumptive binding domain of Staphylococcus aureus autolysin.
- Journal:Microbiol. Immunol.,2000,(44):463-472 [PubMed:10941929]
- [3] Schneewind O.,Baba T.,
- Title:Targeting of muralytic enzymes to the cell division site of Gram-positive bacteria: repeat domains direct autolysin to the equatorial surface ring of Staphylococcus aureus.
- Journal:EMBO J.,1998,(17):4639-4646 [PubMed:9707423]
- [4] Matsumoto A.,Yamada S.,Nakashima S.,Sugai M.,Komatsuzawa H.,
- Title:Subcellular localization of the major autolysin, ATL and its processed proteins in Staphylococcus aureus.
- Journal:Microbiol. Immunol.,1997,(41):469-479 [PubMed:9251058]
- [5] Matsumoto A.,Komatsuzawa H.,Nakashima S.,Yamada S.,Sugai M.,
- Title:Localized perforation of the cell wall by a major autolysin: atl gene products and the onset of penicillin-induced lysis of Staphylococcus aureus.
- Journal:J. Bacteriol.,1997,(179):2958-2962 [PubMed:9139914]
- [6] Oshida T.,Nakashima S.,Komatsuzawa H.,Sugai M.,Yamada S.,
- Title:An autolysin ring associated with cell separation of Staphylococcus aureus.
- Journal:J. Bacteriol.,1996,(178):1565-1571 [PubMed:8626282]
- [7] Oshida T.,Hong Y.-M.,Akiyama T.,Komatsuzawa H.,Sugai M.,
- Title:Identification of endo-beta-N-acetylglucosaminidase and N-acetylmuramyl-L-alanine amidase as cluster-dispersing enzymes in Staphylococcus aureus.
- Journal:J. Bacteriol.,1995,(177):1491-1496 [PubMed:7883705]