Record in detail
- Enzy_Id:EN98666809
Name:LYS_BPCP1
FullName:phage Cp-1 lysin,Cpl-1
Producer Organism:Streptococcus phage Cp-1
Sequence Length:339
Mass:39190
Isoelectric Point:4.38
Target:S. pneumoniae
Link:P15057 - Function:Responsible for the separation of the host daughter cells at the end of cell division and participates in the liberation of progeny bacteriophage into the medium. Strictly depends on the presence of choline-containing cell walls for activity.
- Antibacterial Activities
No MICs found on enzybiotics database
- Sequence
- MVKKNDLFVDVSSHNGYDITGILEQMGTTNTIIKISESTTYLNPCLSAQVEQSNPIGFYH FARFGGDVAEAEREAQFFLDNVPMQVKYLVLDYEDDPSGDAQANTNACLRFMQMIADAGY KPIYYSYKPFTHDNVDYQQILAQFPNSLWIAGYGLNDGTANFEYFPSMDGIRWWQYSSNP FDKNIVLLDDEEDDKPKTAGTWKQDSKGWWFRRNNGSFPYNKWEKIGGVWYYFDSKGYCL TSEWLKDNEKWYYLKDNGAMATGWVLVGSEWYYMDDSGAMVTGWVKYKNNWYYMTNERGN MVSNEFIKSGKGWYFMNTNGELADNPSFTKEPDGLITVA
- Domains
- 1 Name:Cell_wall/Cho-bd_repeat Interpro Link:IPR018337
- 2 Name:Glyco_hydro_25 Interpro Link:IPR002053
- 3 Name:Glyco_hydro_25_AS Interpro Link:IPR008270
- 4 Name:Glyco_hydro_fam25_subgr Interpro Link:IPR018077
- 5 Name:Glyco_hydro_subgr_catalytic Interpro Link:IPR013781
- 6 Name:Glycoside_hydrolase_SF Interpro Link:IPR017853
- Structures
- 1
1H09Method:X-ray
Chains:A=2-339 - 2
1OBAMethod:X-ray
Chains:A=1-339 - 3
2IXUMethod:X-ray
Chains:A=1-339 - 4
2IXVMethod:X-ray
Chains:A=1-339 - 5
2J8FMethod:X-ray
Chains:A=1-339 - 6
2J8GMethod:X-ray
Chains:A=1-339
- Reference
- [1] Ahrazem O.,Galan B.,Albert A.,Monterroso B.,Hermoso J.A.,
- Title:Structural basis for selective recognition of pneumococcal cell wall by modular endolysin from phage Cp-1.
- Journal:Structure,2003,(11):1239-1249 [MEDLINE:22890810]
- [2] Garcia P.,Lopez R.,Martin A.C.,
- Title:Analysis of the complete nucleotide sequence and functional organization of the genome of Streptococcus pneumoniae bacteriophage Cp-1.
- Journal:J. Virol.,1996,(70):3678-3687 [MEDLINE:96211500]
- [3] Garcia J.L.,Garcia P.,Sanz J.M.,
- Title:Role of Asp-9 and Glu-36 in the active site of the pneumococcal CPL1 lysozyme: an evolutionary perspective of lysozyme mechanism.
- Journal:Biochemistry,1992,(31):8495-8499 [MEDLINE:93002976]
- [4] Sanchez-Puelles J.M.,Arraras A.,Garcia P.,Garcia J.L.,Garcia E.,
- Title:Molecular evolution of lytic enzymes of Streptococcus pneumoniae and its bacteriophages.
- Journal:Proc. Natl. Acad. Sci. U.S.A.,1988,(85):914-918 [MEDLINE:88124951]